Genetics of fibrotic myopathy in the German Shepherd Dog

Genetics of fibrotic myopathy in the German Shepherd Dog

September 19th, 2019

Breed(s): German Shepherd Dog and other breeds affected with fibrotic myopathy

Study Type: DNA samples obtained from blood

Study Location: University of Wisconsin-Madison

Fibrotic myopathy is a specific clinical syndrome with a highly characteristic presentation of profound hindlimb lameness and fibrous contracture of thigh musculature (semitendinosus and gracilis). Diagnosis can be confirmed by physical examination. One or both hindlimbs may be affected. Affected hindlimbs have a shortened stride with a rapid elastic internal rotation of the foot, external rotation of the hock (ankle) and internal rotation of the stifle (knee) during the swing phase. This characteristic gait is caused by altered stifle and hock range of motion. Palpation of the medial thigh reveals a firm taut band extending from the midline of the pelvis to the caudomedial aspect of the stifle. The gracilis muscle is usually more severely affected than the semitendinosus. Palpation of the affected muscles is often painful. Prognosis for affected dogs is very poor. There is no curative treatment and dogs experience permanent disability. Surgical cutting of the fibrotic band in the thigh is unsuccessful as the contracture recurs within a few months. Medical therapy is generally unsuccessful, although, anecdotally, stem cell injections may help mobility over time.

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Is Canine Epilepsy Associated with Gut Dybiosis?

Is Canine Epilepsy Associated with Gut Dysbiosis?

Participate from home!

The Companion Animal Epilepsy Research program at NC State University College of Veterinary Medicine is recruiting for a new clinical trial to determine whether dogs with idiopathic epilepsy have alterations in their gut microbial population. Our study team is looking for households with an epileptic dog and an unaffected dog to compare the bacterial populations within their gastrointestinal tract. Feces will be collected from both dogs to compare their gut microbiome.

PARTICIPATION-

  • Owners must be willing to collect a one-time fecal sample from both dogs and send samples to NCSU CVM (pre-paid shipping). Owners will also be required to complete a brief online questionnaire at the time of sample collection.

Read more: Is Canine Epilepsy Associated with Gut Dybiosis?